Human Protein Complexes

Involved in Transcription and/or in the Nucleus

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1. TRANSCRIPTION
  P253  emerin, 9 subunits
  • Cell cycle control
      P081  TFIIH, 10 subunits
      P082  Cak, 3 subunits
      P137  CAK-ECCR2, 4 subunits
  • Cell type-specific
      P250  TAF4b-TFIID, 16 subunits
  • Chromatin modification
    • ATP-dependent chromatin remodeling
        P069  WCRF, 2 subunits
        P074  Fl-Brg1, 10 subunits
        P075  Fl-hBrm, 11 subunits
        P083  SWI/SNF, 11 subunits
        P084  SWI/SNF-A, 12 subunits
        P085  BAF, 11 subunits
        P086  PBAF, 14 subunits
        P088  NuRD.2, 8 subunits
        P091  NuRD.1, 7 subunits
        P093  N-CoR-1, 20 subunits
        P097  SNF2h/cohesin, 17 subunits
        P100  MeCP1, 9 subunits
        P104  Sin3-CI, 15 subunits
        P110  SWI/SNF-B, 12 subunits
        P122  HuCHRAC, 4 subunits
        P123  RSF, 2 subunits
        P138  TIP60, 15 subunits
        P143  WINAC, 14 subunits
        P147  EBAFb, 14 subunits
        P148  ATRX-Daxx, 4 subunits
        P149  p400, 6 subunits
        P152  ALL-1, 29 subunits
        P158  TRRAP/TIP60, 17 subunits
        P170  NUMAC, 9 subunits
        P173  PBAF.2, 13 subunits
        P176  DMAP1, 15 subunits
        P192  WICH, 2 subunits
        P193  hNURF, 4 subunits
        P195  HDAC1, 10 subunits
        P197  HDAC2-c, 6 subunits
        P204  SRCAP, 9 subunits
        P212  LARC, 19 subunits
        P215  hINO80, 13 subunits
        P219  NRD, 7 subunits
        P228  B-WICH, 8 subunits
        P248  GST-Smad2, 8 subunits
        P249  GST-Smad3, 10 subunits
        P257  emerin C32, 14 subunits
    • Chromatin remodeling
        P187  DNMT3B, 8 subunits
    • Histone acetyltransferase
        P047  TRRAP/GCN5, 11 subunits
        P068  TFTC, 19 subunits
        P072  STAGA, 19 subunits
        P073  PCAF, 25 subunits
        P138  TIP60, 15 subunits
        P139  c-Myc, 6 subunits
        P152  ALL-1, 29 subunits
        P158  TRRAP/TIP60, 17 subunits
        P175  NuA4, 15 subunits
        P177  picNuA4, 3 subunits
        P216  hMSL, 4 subunits
        P217  hMOF, 7 subunits
        P223  BRCA1-TRRAP/hGCN5, 10 subunits
        P225  ING3-TAP, 14 subunits
        P226  ING4-TAP, 6 subunits
        P227  ING5-TAP, 11 subunits
        P244  2A-DUB, 8 subunits
        P277  MLL1-WDR5, 29 subunits
    • Histone acetyltransferase inhibitor
        P141  INHAT, 3 subunits
    • Histone deacetylase
        P059  BHC, 6 subunits
        P060  BRAF35/BRCA2, 7 subunits
        P088  NuRD.2, 8 subunits
        P089  Sin3, 8 subunits
        P091  NuRD.1, 7 subunits
        P093  N-CoR-1, 20 subunits
        P094  N-CoR-2, 20 subunits
        P095  N-CoR-HDAC3, 6 subunits
        P096  SMRT, 4 subunits
        P097  SNF2h/cohesin, 17 subunits
        P100  MeCP1, 9 subunits
        P103  Sin3-CII, 8 subunits
        P104  Sin3-CI, 15 subunits
        P111  HDAC1-PP1, 6 subunits
        P118  N-CoR, 7 subunits
        P119  XFIM, 4 subunits
        P120  HDAC2, 17 subunits
        P121  BHC110, 13 subunits
        P135  mSin3A, 11 subunits
        P146  MTA1-HDAC, 8 subunits
        P152  ALL-1, 29 subunits
        P187  DNMT3B, 8 subunits
        P190  HCF-1N, 16 subunits
        P195  HDAC1, 10 subunits
        P196  HDAC1-cI, 3 subunits
        P197  HDAC2-c, 6 subunits
        P211  LSD1.com, 15 subunits
        P212  LARC, 19 subunits
        P219  NRD, 7 subunits
        P222  mSin3-HDAC, 8 subunits
        P224  ING2-TAP, 12 subunits
        P234  CtBP, 16 subunits
    • Histone demethylase
        P059  BHC, 6 subunits
        P060  BRAF35/BRCA2, 7 subunits
        P119  XFIM, 4 subunits
        P120  HDAC2, 17 subunits
        P121  BHC110, 13 subunits
        P152  ALL-1, 29 subunits
        P195  HDAC1, 10 subunits
        P196  HDAC1-cI, 3 subunits
        P211  LSD1.com, 15 subunits
        P237  BCOR, 8 subunits
    • Histone deubiquitination
        P068  TFTC, 19 subunits
        P072  STAGA, 19 subunits
        P244  2A-DUB, 8 subunits
    • Histone methyltransferase
        P070  E2F6.com-1, 12 subunits
        P092  EED-EZH2, 5 subunits
        P107  PRC2, 5 subunits
        P151  ASCOM, 9 subunits
        P152  ALL-1, 29 subunits
        P157  SETDB1, 2 subunits
        P170  NUMAC, 9 subunits
        P178  menin HMTase, 7 subunits
        P185  PRC3, 5 subunits
        P187  DNMT3B, 8 subunits
        P190  HCF-1N, 16 subunits
        P191  MLL/HCF, 9 subunits
        P234  CtBP, 16 subunits
        P238  PTIP.com, 10 subunits
        P239  CFP1, 6 subunits
        P262  ALR, 11 subunits
        P266  Set1B, 6 subunits
        P277  MLL1-WDR5, 29 subunits
  • Coactivator
  • Couple transcription to mRNA export
      P053  TREX, 5 subunits
  • DNA binding
      P119  XFIM, 4 subunits
      P120  HDAC2, 17 subunits
      P121  BHC110, 13 subunits
      P139  c-Myc, 6 subunits
      P261  DYX1C1 transcription, 3 subunits
    • Component of MHCII enhanceosome
        P260  RFX, 3 subunits
    • MAF recognition element MARE
        P212  LARC, 19 subunits
    • Methyl CpG binding
        P118  N-CoR, 7 subunits
    • Methyl-CpG binding
        P097  SNF2h/cohesin, 17 subunits
        P100  MeCP1, 9 subunits
    • Sequence specific
        P143  WINAC, 14 subunits
        P148  ATRX-Daxx, 4 subunits
  • Elongation
      P208  hPAF, 5 subunits
    • Facilitate elongation through nucleosomes
        P019  FACT, 2 subunits
        P180  FACT-Nek9, 3 subunits
        P181  p53 Ser-392 kinase, 5 subunits
    • Histone acetyltransferase
        P046  Elongator, 6 subunits
    • Holo-elongator
        P046  Elongator, 6 subunits
    • Inactive form of positive transcription elongation factor
        P140  P-TEFb/7SK RNA, 3 subunits
        P240  BCDIN3-TAP, 5 subunits
    • Negative transcription elongation factor
        P040  NELF, 5 subunits
    • Positive transcription elongation factor
        P042  P-TEFb.1, 2 subunits
        P043  P-TEFb.2, 2 subunits
        P044  P-TEFb.3, 2 subunits
        P045  P-TEFb.4, 2 subunits
    • Protein kinase
        P181  p53 Ser-392 kinase, 5 subunits
    • Regulate RNAPII processivity
        P039  DSIF, 2 subunits
    • Repress FCP1
        P126  CK2, 3 subunits
    • RNAPII CTD dephosphorylation
        P112  Flag-FCP1, 8 subunits
    • Suppress RNAPII transient pausing
        P101  TFIIF, 2 subunits
    • Transition from initiation to elongation
        P081  TFIIH, 10 subunits
  • General transcription factor
      P029  TFIID, 16 subunits
      P071  TFIIA, 2 subunits
      P081  TFIIH, 10 subunits
      P101  TFIIF, 2 subunits
      P102  TFIIE, 2 subunits
      P251  TAF4-TFIID, 15 subunits
  • Histone binding
      P141  INHAT, 3 subunits
  • Initiation
      P050  DAB, 19 subunits
      P071  TFIIA, 2 subunits
      P208  hPAF, 5 subunits
    • ATP-dependent
        P024  hB-TFIID, 2 subunits
    • ATP-dependent promoter melting
        P081  TFIIH, 10 subunits
    • ATP-independent promoter melting
        P102  TFIIE, 2 subunits
    • DNA binding
        P029  TFIID, 16 subunits
    • Preinitiation complex assembly
        P029  TFIID, 16 subunits
        P250  TAF4b-TFIID, 16 subunits
        P251  TAF4-TFIID, 15 subunits
    • RNAPII binding
        P101  TFIIF, 2 subunits
  • Mediator
      P002  TRAP/SMCC, 28 subunits
      P003  ARC, 15 subunits
      P004  DRIP, 17 subunits
      P005  CRSP, 9 subunits
      P006  PC2, 19 subunits
      P007  NAT, 18 subunits
      P008  Srb/Mediator, 6 subunits
      P161  A-Med, 13 subunits
      P162  TR-TRAP, 19 subunits
      P174  mMediator, 32 subunits
    • Promoter specific
        P202  CRSP/Med2, 12 subunits
  • Nutrient signaling
    • MTOR pathway
        P159  PFD-like, 13 subunits
  • Repression
    • Activator dephosphorylation
        P111  HDAC1-PP1, 6 subunits
    • Blocking ATP-dependent remodeling
        P194  inactive hNURF, 4 subunits
    • Corepressor
        P089  Sin3, 8 subunits
        P093  N-CoR-1, 20 subunits
        P094  N-CoR-2, 20 subunits
        P095  N-CoR-HDAC3, 6 subunits
        P096  SMRT, 4 subunits
        P103  Sin3-CII, 8 subunits
        P104  Sin3-CI, 15 subunits
        P118  N-CoR, 7 subunits
        P119  XFIM, 4 subunits
        P120  HDAC2, 17 subunits
        P121  BHC110, 13 subunits
        P135  mSin3A, 11 subunits
        P187  DNMT3B, 8 subunits
        P190  HCF-1N, 16 subunits
        P211  LSD1.com, 15 subunits
        P222  mSin3-HDAC, 8 subunits
        P224  ING2-TAP, 12 subunits
        P234  CtBP, 16 subunits
        P237  BCOR, 8 subunits
        P257  emerin C32, 14 subunits
    • Histone ubiquitylation
        P237  BCOR, 8 subunits
  • RNA pol I transcription
      P228  B-WICH, 8 subunits
  • RNA pol III transcription
      P228  B-WICH, 8 subunits
  • RNA polymerase II
      P066  RNA polymerase II, 12 subunits
      P241  TAP-tagged RNAPII, 17 subunits
    • Mediator-dependent transcription
        P232  PolII(G), 13 subunits
  • RNAPII-dependent
      P213  Integrator, 17 subunits
      P214  DSS1, 31 subunits
  • Silencing
    • Block polynucleosomal remodeling
        P106  hPRC-H, 10 subunits
    • Polycomb-mediated
        P092  EED-EZH2, 5 subunits
        P107  PRC2, 5 subunits
        P185  PRC3, 5 subunits
  • Transcription-coupled DNA repair
      P113  BASC(Ab81), 6 subunits
      P114  BASC(Ab80), 8 subunits
      P115  BASC(C20), 3 subunits
      P223  BRCA1-TRRAP/hGCN5, 10 subunits

2. TELOMERE MAINTENANCE
3. SIGNAL TRANSDUCTION
  P255  emerin C25, 13 subunits
  P256  emerin C52, 17 subunits
4. RNA PROCESSING
  P254  emerin C24, 7 subunits
  P255  emerin C25, 13 subunits
  P256  emerin C52, 17 subunits
  • Methylation and assembly of snRNP core particles
      P112  Flag-FCP1, 8 subunits
  • Pre-mRNA splicing
      P072  STAGA, 19 subunits
      P203  CDC5L, 6 subunits
  • Repress
      P127  ASAP-L, 3 subunits
      P128  ASAP-S, 3 subunits
  • RNA splicing
      P273  CNOT7-CNOT6, 9 subunits
      P274  CNOT7-CNOT6L, 9 subunits
      P275  CNOT8-CNOT6, 9 subunits
      P276  CNOT8-CNOT6L, 9 subunits
  • SnRNA 3’-end processing
      P213  Integrator, 17 subunits
      P214  DSS1, 31 subunits

5. RNA EXPORT
  P273  CNOT7-CNOT6, 9 subunits
  P274  CNOT7-CNOT6L, 9 subunits
  • Couple transcription to mRNA export
      P053  TREX, 5 subunits

6. RNA DEGRADATION
  • 3' to 5' mRNA degradation
      P208  hPAF, 5 subunits
      P210  hSKI, 3 subunits

7. DNA REPLICATION
  P054  DNA synthesome, 15 subunits
  P057  RP-A, 3 subunits
  P079  Mcm4,6,7, 3 subunits
  P080  Mcm2,4,6,7, 4 subunits
  P113  BASC(Ab81), 6 subunits
  P114  BASC(Ab80), 8 subunits
  P124  cohesin-1, 4 subunits
  P125  cohesin-2, 4 subunits
  P175  NuA4, 30 subunits
  P225  ING3-TAP, 14 subunits
  P227  ING5-TAP, 11 subunits
  P228  B-WICH, 8 subunits
  P229  CUL4/DDB1, 5 subunits
  P230  L2DTL, 10 subunits
  P254  emerin C24, 7 subunits
  • Chromatin assembly
      P105  CAF-1, 3 subunits
    • Heterochromatin assembly
        P192  WICH, 2 subunits
  • Chromatin modification
    • ATP-dependent chromatin remodeling
        P143  WINAC, 14 subunits
  • PCNA clamp loader
      P055  RF-C, 5 subunits
  • Replication origin
      P078  ORC, 6 subunits

8. DNA REPAIR
  P055  RF-C, 5 subunits
  P188  FANCA-core, 9 subunits
  P252  SMC5-6, 6 subunits
  • DNA binding
    • Damaged DNA binding
        P068  TFTC, 19 subunits
        P072  STAGA, 19 subunits
    • Structural DNA
        P138  TIP60, 15 subunits
        P158  TRRAP/TIP60, 17 subunits
  • DNA damage repair
  • DNA damage response
      P116  MRE11, 3 subunits
      P117  hRAD50-hMRE11, 5 subunits
      P229  CUL4/DDB1, 5 subunits
      P230  L2DTL, 10 subunits
      P231  BRCA1/BARD1, 9 subunits
      P271  hSSB1, 3 subunits
      P272  hSSB2, 3 subunits
  • DNA damage sensor
      P113  BASC(Ab81), 6 subunits
      P114  BASC(Ab80), 8 subunits
      P115  BASC(C20), 3 subunits
      P223  BRCA1-TRRAP/hGCN5, 10 subunits
  • Genomic maintenance
    • DNA unwinding
        P131  BRAFT, 14 subunits
        P132  BLM-CII, 8 subunits
        P133  BLM-CIII, 6 subunits
        P134  FANCA, 13 subunits
    • Regulate Fanconi anemia pathway
        P246  USP1/UAF1, 2 subunits
  • Homologous recombination repair
      P268  BRCA, 5 subunits
  • Nonhomologous DNA end joining
      P041  Artemis/DNA-PKcs, 2 subunits
  • Nucleotide excision
      P081  TFIIH, 10 subunits
      P137  CAK-ECCR2, 4 subunits
    • Stimulate mismatch repair
        P260  RFX, 3 subunits
  • Transcription-coupled repair
      P113  BASC(Ab81), 6 subunits
      P114  BASC(Ab80), 8 subunits
      P115  BASC(C20), 3 subunits
      P223  BRCA1-TRRAP/hGCN5, 10 subunits

9. DNA RECOMBINATION
  P252  SMC5-6, 6 subunits
10. DNA METABOLISM
  • Telomere protection
      P278  CST, 3 subunits

11. DNA BINDING
  • Repetitive DNA
      P187  DNMT3B, 8 subunits
  • Single-stranded DNA binding
      P278  CST, 3 subunits

12. CHROMOSOME STABILITY
13. CELL GROWTH
  P190  HCF-1N, 16 subunits
  • Nutrient signaling
    • Cell size control
        P130  NSC, 4 subunits
  • Oncogenic transformation cofactor
      P139  c-Myc, 6 subunits
  • Telomere maintenance
    • Negative regulator
        P189  hRap1, 7 subunits

14. CELL CYCLE PROGRESSION
  P060  BRAF35/BRCA2, 7 subunits
  P229  CUL4/DDB1, 5 subunits
  P230  L2DTL, 10 subunits
  • Centromere structure
      P269  CENP-A NAC, 6 subunits
      P270  ICEN, 40 subunits
  • Interphase
      P180  FACT-Nek9, 3 subunits

15. CELL CYCLE
  • Chromosome condensation
      P186  condensin, 5 subunits
      P187  DNMT3B, 8 subunits
  • DNA damage checkpoint
      P267  9-1-1, 3 subunits
  • G2/M checkpoint maintenance
      P280  DNA-PKcs-PIDDosome, 3 subunits
  • Sister chromatid cohesion
      P124  cohesin-1, 4 subunits
      P125  cohesin-2, 4 subunits

16. APOPTOSIS
  • Accelerate cell death
      P127  ASAP-L, 3 subunits
      P128  ASAP-S, 3 subunits

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