Yeast Protein Complexes

Involved in Transcription and/or in the Nucleus

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PINMIPS

1. TRANSCRIPTION
  • Chromatin association
      P168  NAP-Z, 3 subunits
  • Chromatin modification
    • ATP-dependent chromatin remodeling
        P009  ISW1b, 3 subunits
        P010  ISW2, 4 subunits
        P012  SWI/SNF, 12 subunits
        P030  RSC, 18 subunits
        P165  SWR1, 12 subunits
        P166  INO80.com, 15 subunits
        P167  Htz1 coms, 18 subunits
        P169  SWR-C, 13 subunits
        P179  RSCa, 16 subunits
        P182  ISW2/yCHRAC, 4 subunits
        P265  ISW1a, 2 subunits
    • Histone acetyltransferase
        P013  NuA4, 13 subunits
        P014  NuA3, 2 subunits
        P015  SAGA, 21 subunits
        P016  ADA, 4 subunits
        P026  SAS, 3 subunits
        P048  Elongator, 3 subunits
        P049  holo-Elongator, 12 subunits
        P142  picNuA4, 3 subunits
        P164  SLIK, 17 subunits
        P207  SALSA, 12 subunits
    • Histone deacetylase
        P025  Sin3-Rpd3, 6 subunits
        P258  Rpd3S, 5 subunits
        P259  Rpd3L, 12 subunits
    • Histone methyltransferase
        P031  COMPASS, 7 subunits
        P034  Set1C, 8 subunits
        P090  Set1p, 7 subunits
        P144  Set2, 11 subunits
    • Nucleosome reorganizing
        P021  SPN, 4 subunits
  • Couple transcription to mRNA export
      P052  TREX, 9 subunits
      P129  Sac3-Thp, 4 subunits
  • DNA binding
      P032  SBF, 2 subunits
      P033  MBF, 2 subunits
      P037  Mcm1-SFF, 2 subunits
      P218  HIR, 4 subunits
    • ATP-dependent TBP dissociation from promoter
        P198  Mot1-TBP, 2 subunits
  • Elongation
      P049  holo-Elongator, 6 subunits
      P058  Paf1-RNA polymerase II, 20 subunits
      P061  Hap, 3 subunits
      P145  Paf1, 5 subunits
    • Elongator core
        P048  Elongator, 3 subunits
    • Facilitate elongation through nucleosomes
        P020  Spt16-Pob3, 2 subunits
    • Holo-elongator
        P049  holo-Elongator, 6 subunits
    • Link transcription elongation with mitotic recombination
        P051  THO, 4 subunits
    • RNAPII
        P144  Set2, 11 subunits
    • Transition from initiation to elongation
        P154  holo-TFIIH, 10 subunits
        P155  TFIIK, 3 subunits
  • General transcription factor
      P018  TFIID, 16 subunits
      P153  core TFIIH, 6 subunits
      P155  TFIIK, 3 subunits
      P264  TFIIF, 3 subunits
    • Mediator
        P001  Mediator, 24 subunits
        P022  PolII-Med, 36 subunits
        P064  Srb4, 8 subunits
    • Mediator core
        P023  Medc, 13 subunits
  • Initiation
      P022  PolII-Med, 36 subunits
      P028  CPF, 16 subunits
      P058  Paf1-RNA polymerase II, 20 subunits
    • ATP-dependent promoter melting
        P153  core TFIIH, 6 subunits
        P154  holo-TFIIH, 10 subunits
    • Preinitiation complex assembly
        P018  TFIID, 16 subunits
    • Reinitiation
        P171  PolII-TFIIF, 15 subunits
  • Mediator
      P001  Mediator, 24 subunits
      P022  PolII-Med, 36 subunits
      P063  Med9/10, 6 subunits
      P064  Srb4, 8 subunits
      P065  Srb8-11, 4 subunits
      P156  Srb8/9/10/11, 4 subunits
    • Mediator core
        P023  Medc, 13 subunits
  • mRNA initiation, elongation, and degradation
      P035  1.0 Mda CCR4-NOT, 9 subunits
  • Nucleolar silencing
      P067  RENT, 4 subunits
  • Repression
    • Nucleosome assemply
        P218  HIR, 4 subunits
    • Reinitiation repressor
        P136  capping enzyme, 2 subunits
  • RNA polymerase II
      P062  RNA polymerase II, 12 subunits

2. RNA PROCESSING
  • mRNA cleavage and polyadenylation factor
    • mRNA 3'-end processing
        P028  CPF, 16 subunits
  • Pre-mRNA processing
  • RNA polyadenylation
      P206  TRAMP, 3 subunits

3. RNA METABOLISM
  • Cleavage of RNA-DNA hybrids
      P172  RNAse H2, 3 subunits

4. RNA EXPORT
  • Couple transcription to mRNA export
      P052  TREX, 9 subunits
      P129  Sac3-Thp, 4 subunits
  • RNA binding
      P129  Sac3-Thp, 4 subunits

5. RNA DEGRADATION
  P035  1.0 Mda CCR4-NOT, 9 subunits
  • 3' to 5' mRNA degradation
      P209  SKI, 3 subunits
  • Exosome cofactor
      P206  TRAMP, 3 subunits

6. RIBOSOME BIOGENESIS
  P076  Yph1-S, 3 subunits
  P077  Yph1-L, 18 subunits
7. DNA REPLICATION
  P076  Yph1-S, 3 subunits
  P077  Yph1-L, 18 subunits
  • Chromatin accessibility
      P010  ISW2, 4 subunits
    • Telomeric silencing
        P184  HAT-B, 3 subunits
  • Chromatin accessiblity
      P182  ISW2/yCHRAC, 4 subunits
  • Chromatin modification
    • ATP-dependent chromatin remodeling
        P010  ISW2, 4 subunits
        P012  SWI/SNF, 12 subunits
        P182  ISW2/yCHRAC, 4 subunits
    • Histone acetyltransferase
        P184  HAT-B, 3 subunits
    • Nucleosome reorganizing
        P021  SPN, 4 subunits
  • DNA replisome component
      P183  Pol epsilon, 4 subunits
  • Inheritance of telomeric silencing
      P183  Pol epsilon, 4 subunits
  • PCNA clamp loader
      P056  RF-C, 5 subunits
  • Removal of Okazaki primers
      P172  RNAse H2, 3 subunits
  • Replication initiation and elongation
  • Replisome component
    • Pol epsilon accessory factor
        P236  GINS, 4 subunits

8. DNA REPAIR
  P056  RF-C, 5 subunits
  P183  Pol epsilon, 4 subunits
  P205  Mms21-Smc5-Smc6, 8 subunits
  • DNA damage repair
      P166  INO80.com, 15 subunits
  • Excision of misincorporated ribonucleotides
      P172  RNAse H2, 3 subunits
  • Nucleotide excision
      P153  core TFIIH, 6 subunits
      P154  holo-TFIIH, 10 subunits

9. DNA RECOMBINATION
  • Chromatin modification
    • ATP-dependent chromatin remodeling
        P012  SWI/SNF, 12 subunits
  • DNA damage resistance
    • Structure-specific endonuclease
        P027  Mms4-Mus81, 2 subunits
  • Mitotic recombination
      P051  THO, 4 subunits

10. DNA METABOLISM
  • Telomere protection
      P279  CST, 3 subunits
  • Telomere uncapping and elongation
    • Regulator of telomere uncapping and elongation
        P221  KEOPS, 6 subunits

11. DNA BINDING
  • Single-stranded DNA binding
      P279  CST, 3 subunits

12. CELL GROWTH
  • Nutrient signaling
    • Cell size control
        P242  TORC1, 3 subunits
        P243  TORC2, 5 subunits

13. CELL CYCLE PROGRESSION
  • Chromatin modification
    • ATP-dependent chromatin remodeling
        P030  RSC, 18 subunits
        P179  RSCa, 16 subunits
    • Histone acetyltransferase
        P235  Rtt109-Vps75, 2 subunits

14. CELL CYCLE
  • Anaphase promoting
    • Ubiquitin ligase
        P220  APC, 13 subunits


500 Translation complexes
500.10 Cytoplasmic translation initiation
     500.10.110 eIF4E/eIF4G/Pab1p complex
     500.10.20 eIF2
     500.10.40 eIF3
     500.40.10 cytoplasmic ribosomal large subunit
     500.40.20 cytoplasmic ribosomal small subunit
   500.50 Mitochondrial translation complexes
     500.60.10 mitochondrial ribosomal large subunit
     500.60.20 mitochondrial ribosomal small subunit

510 Transcription complexes/Transcriptosome
   510.10 RNA polymerase I
   510.100 TFIIH
   510.110 TFIIK (CTD kinase)
   510.120 RNA polymerase III
   510.130 TFIIIA
   510.140 TFIIIB
   510.150 TFIIIC
   510.160 CCAAT-binding factor complex
   510.170 mRNA guanylyl transferase (capping complex)
       510.180.10.10 NEF1 complex
       510.180.10.20 NEF2 complex
       510.180.10.30 NEF3 complex
       510.180.10.40 NEF4 complex
     510.180.20 other DNA repair complexes
       510.180.30.10 Ku complex
       510.180.30.20 DNA ligase IV
       510.180.30.30 MRE11/RAD50/XRS2 complex
       510.180.50.10 MSH2/MSH3 complex
       510.180.50.20 MSH2/MSH6 complex
       510.180.50.30 MLH1/PMS1 complex
     510.190.10 ADA complexes
       510.190.10.10 ADA complex
         510.190.10.20.10 SAGA complex
         510.190.10.20.20 SAGA-like complex (SLIK)
     510.190.100 OAF complex
     510.190.110 CCR4 complex
     510.190.120 ARG complex
     510.190.130 RTG complex
     510.190.140 Tup1/Ssn6 complex
     510.190.150 Sin3 complex
       510.190.160.10 Cbf1/Met4/Met28 complex
       510.190.160.20 Met4/Met28/Met31 complex
       510.190.160.30 Met4/Met28/Met32 complex
     510.190.180 Mot1 complex
     510.190.190 NC2 complex
     510.190.20 HPR1 complex
     510.190.200 Ume6/Ime1 complex
     510.190.210 LEU3 complex
     510.190.30 NAC complex
     510.190.40 NOT complex
     510.190.50 SWI/SNF transcription activator complex
     510.190.60 SBF complex
     510.190.70 MBF complex
     510.190.80 GAL80 complex
     510.190.90 GCR complex
   510.20 Core Factor (CF)
   510.30 Upstream Activation Factor (UAF) complex
   510.40 RNA polymerase II holoenzyme
     510.40.10 RNA polymerase II
     510.40.20 Kornberg's mediator (SRB) complex
   510.50 TFIIA
   510.60 TFIIB
     510.70.10 TBP
     510.70.20 TAFIIs
   510.80 TFIIE
   510.90 TFIIF

520 Translocon
   520.30 Signal peptidase
   520.40 Signal recognition particle (SRP)
   520.50 Signal recognition particle receptor (SR)

400 RSC complex (Remodel the structure of chromatin)

410 Replication complexes
   410.10 Post-replication complex (Origin recognition complex=ORC )
   410.20 Replication initiation complex
   410.30 Pre-replication complex (pre-RC)
   410.33 
   410.35 Replication complex
     410.40.10 PCNA
     410.40.100 DNA polymerase epsilon (II)
     410.40.110 DNA polymerase zeta
     410.40.120 Exonucleases
     410.40.130 RNase H1
     410.40.140 Topoisomerases
     410.40.20 Replication factor A complex
     410.40.30 Replication factor C complex
     410.40.40 DNA helicases
     410.40.50 DNA ligases
     410.40.60 DNA polymerase alpha (I) - primase complex
     410.40.70 DNA polymerase beta (IV)
     410.40.90 DNA polymerase delta (III)
   410.50 Telomerase

420 Respiration chain complexes
   420.60 other respiration chain complexes

430 Ribonucleoside-diphosphate reductase

440 RNA processing complexes
   440.10 Nuclear processing complexes
     440.10.10 pre mRNA3'-end processing factor CFI
     440.10.20 pre mRNA3'-end processing factor CFII
     440.10.30 pre mRNA polyadenylation factor PFI
     440.12.10 Exosome complex
     440.12.20 RNase MRP
     440.12.30 Nop56p/Nop1p complex
     440.14.10 RNase P
   440.30 Nuclear splicing complexes/Spliceosome
     440.30.10 mRNA splicing
       440.30.10.10 Prp19p-associated complex
       440.30.10.20 Prp9p/Prp11p/Prp21p complex
     440.30.20 rRNA splicing
     440.30.30 tRNA splicing
   440.90 other RNA processing components

445 SCF (Skp1-Cdc53-F-box protein) comlexes
   445.10 SCF-CDC4 complex
   445.20 SCF-GRR1 complex
   445.30 SCF-MET30 complex

450 Serine/threonine phoshpoprotein phosphatase

470 Signal transduction complexes
   470.10 SNF1 complex
   470.20 STE5-MAPK complex

475 Nuclear cohesion
   475.05 Sister chromatid cohesion complex
   475.10 Sister chromatid separation complex

480 Spindle pole body (SPB)
   480.10 SPB components
     480.10.05 gamma-tubulin complex
   480.20 SPB associated proteins

490 Synaptonemal complex (SC)

300 Nonsense-mediated mRNA decay pathway complex

310 Nuclear pore complex (NPC)
   310.10 NSP1 complex
   310.20 NSP1-NUP82 complex
   310.30 NSP1-NIC96 complex
   310.40 NUP84 complex

320 Nucleosomal protein complex

325 Ornithine carbamoyltransferase

360 Proteasome
   360.10 26S proteasome
     360.10.10 20S proteasome
     360.10.20 19/22S regulator

370 Protein N-acetyltransferase

225 Hexokinase 2

230 Histone acetyltransferase complexes
   230.10 HAT B complex
     230.20.10 ADA complex
     230.20.20 SAGA complex
     230.20.40 NuA4 complex

240 Histone deacetylase complexes
   240.10 HDA complex
   240.20 HDB complex

250 Isocitrate dehydrogenase

260 Intracellular transport complexes
   260.100 Aut2p/Aut7p complex
     260.30.10 COPI
     260.30.20 COPII
     260.50.10 t-SNAREs
     260.50.20 v-SNAREs
   260.60 TRAPP (Transport Protein Particle) complex
   260.90 Arp2p/Arp3p complex

270 Kinetochore protein complexes
   270.10 Inner Kinetochor Protein Complex
     270.10.10 CBF3 protein complex
     270.20.10 Ctf19 protein complex
     270.20.20 Ctf3 protein complex
     270.20.30 Dam1 protein complex
     270.20.40 Ndc80 protein complex
     270.20.50 Chl4 protein complex

290 Mitochondrial translocase complex
   290.10 TOM - transport across the outer membrane
     290.20.20 Tim17p-complex

295 Nem1p-Spo7p complex

100 Calcineurin B

110 cAMP-dependent protein kinase

120 Casein kinase
   120.10 Casein kinase I
   120.20 Casein kinase II

123 Catalase
   123.10 Catalase A

125 Cell cycle checkpoint complexes
125.10 DNA damage checkpoint
     125.10.10 Ddc1p-Mec3p complex

133 Cyclin-CDK (Cyclin-dependent kinases) complexes
   133.10 Cdc28p complexes
   133.20 Pho85p complexes
   133.30 Kin28p complex
   133.40 Srb10p complex
   133.50 Ctk1p complex

140 Cytoskeleton
140.20 Actin filaments
     140.20.10 Actins
     140.20.20 Actin-associated proteins
     140.30.10 Tubulins
     140.30.20 Tubulin-associated proteins
       140.30.30.10 Kinesin-related motorproteins
       140.30.30.20 Dynein-complex motorproteins

143 D-arabinose dehydrogenase

177 Gim complexes

180 Prenyltransferases
   180.20 Geranylgeranyltransferase I (GGTase I)
   180.30 Geranylgeranyltransferase II (GGTase II)

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